Modulation of LIN28B/Let-7 Signaling by Propranolol Contributes to Infantile Hemangioma Involution
نویسندگان
چکیده
منابع مشابه
Propranolol therapy for infantile hemangioma.
CONTEXT There has been widespread interest surrounding the use of beta-blockers (i.e. propranolol, timolol, nadolol, acebutolol) in the treatment of infantile hemangiomas (IH). OBJECTIVE To review literature evaluating treatment of IH with propranolol. EVIDENCE ACQUISITION We conducted a literature search on PubMed and investigated for case reports, case series, and controlled trials by usi...
متن کاملWhen to stop propranolol for infantile hemangioma
There is no definitive conclusion regarding the optimal timing for terminating propranolol treatment for infantile hemangioma (IH). A total of 149 patients who underwent detailed color Doppler ultrasound examination were included in this study. The characteristics and propranolol treatment of all patients were summarized and analyzed. Patients were divided into two groups according to the lesio...
متن کاملMechanisms of propranolol action in infantile hemangioma
Infantile hemangioma is a common tumor of infancy. Although most hemangiomas spontaneously regress, treatment is indicated based on complications, risk to organ development and function, and disfigurement. The serendipitous discovery of propranolol, a non-selective β-adrenergic receptor blocker, as an effective means to regress hemangiomas has made this a first-line therapy for hemangioma patie...
متن کامل[Treatment of infantile hemangioma with propranolol].
Infantile hemangiomas are proliferative vascular disorders that occur in the pediatric airway, potentially causing airway narrowing and respiratory stress. It appears in 1 out 10 children, more frequently in girls. Hemangiomas are benign tumours that usually appear on the head or neck but may also occur in deep organs. Until recently, the most common medical therapy used was high-dose systemic ...
متن کاملPropranolol therapy for infantile hemangioma: our experience
OBJECTIVE Hemangiomas are the most common benign vascular tumors of infancy. Although most infantile hemangiomas (IHs) have the ability to involute spontaneously after initial proliferation and resolve without consequence, intervention is required in a subset of IHs, which develop complications resulting in ulceration, bleeding, or aesthetic deformity. The primary treatment for this subset of I...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2018
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.118.310908